78 research outputs found
Semi-quantitative assessment of right ventricular function in comparison to a 3D volumetric approach: A cardiovascular magnetic resonance study
Right ventricular (RV) volume
measurements with cardiovascular
magnetic resonance (CMR) is
considered the gold standard, but
acquisition and analysis remain timeconsuming.
The aim of our study was
therefore to investigate the accuracy
and performance of a semi-quantitative
assessment of RV function in
CMR, compared to the standard
quantitative approach. Seventy-five
subjects with pulmonary hypertension
(15), anterior myocardial infarction
(15), inferior myocardial infarction
(15), Brugada syndrome (15)
and normal subjects (15) underwent
cine CMR. RV end-systolic and enddiastolic
volumes were determined to
calculate RV ejection fraction (EF).
Four-chamber cine images were used
to measure tricuspid annular plane
systolic excursion (TAPSE). RV fractional
shortening (RVFS) was calculated
by dividing TAPSE by the RV
end-diastolic length. RV EF correlated
significantly with TAPSE (r = 0.62,
p < 0.01) and RVFS (r = 0.67, p < 0.01).
Sensitivity to predict RV dysfunction
was comparable between TAPSE and
RVFS, with higher specificity for
RVFS, but comparable areas under the
ROC curve. Intra- and inter-observer
variability of RV EF was better than
TAPSE (3%/4% versus 7%/15%,
respectively). For routine screening in
clinical practice, TAPSE and RVFS
seem reliable and easy methods to
identify patients with RV dysfunction.
The 3D volumetric approach is preferred
to assess RV function for
research purposes or to evaluate
treatment response
Impact of alcohol septal ablation on left anterior descending coronary artery blood flow in hypertrophic obstructive cardiomyopathy
Objectives: The aim of this study was to evaluate the effects of alcohol septal ablation (ASA) on coronary blood flow in symptomatic hypertrophic obstructive cardiomyopathy (HOCM) using cardiac MR (CMR) coronary flow measurements. Background: CMR flow mapping enables quantification of coronary blood flow in a noninvasive way. Both left ventricular outflow tract (LVOT) gradient reduction and myocardial scarring after ASA are expected to influence left anterior descending (LAD) coronary blood flow. Methods: Cine, contrast-enhanced (CE) imaging and breath-hold CMR phase contrast velocity mapping were performed at baseline and 1 and 6 months after ASA in seven patients. Changes of coronary blood flow were related to left ventricular (LV) mass reduction, enzyme release, volume of ethanol administered, LVOT gradient reduction, and LV rate pressure product (LVRPP). Results: A significant mass reduction was observed bothin the target septal myocardium and in the total myocardium (both P < 0.01). Mean myoca
Разработка прожектора железнодорожного вокзала Томск-1
Основная задача наружного освещения на железных дорогах состоит в том, чтобы дать возможность персоналу и пассажиру определять:
- пространственное расположение и состояние движения подвижного состава;
- обеспечение беспрепятственного выполнения работы;
- препятствия, мешающие безопасному движению;
- железнодорожные сигналы;
- безопасность работы персонала и нахождения пассажиров в зоне железной дороги.
Железная дорога является зоной повышенной опасности, поэтому нет ничего удивительного, что железнодорожное освещение строго нормируется стандартами. Железнодорожные пути, станции и другие объекты нужно освещать на протяжении всей ночи, поэтому оборудование должно быть надежным и экономным.The main task of outdoor lighting on the railways is to enable the personnel and the passenger to determine:
- Spatial location and state of movement of rolling stock;
- ensuring unhindered performance of work;
- obstacles to safe traffic;
- railway signals;
- safety of personnel and the presence of passengers in the railway zone.
The railway is a zone of increased danger, so it is not surprising that railway lighting is strictly standardized by standards. Railway tracks, stations and other objects need to be illuminated throughout the night, so the equipment must be reliable and economical
Early onset and progression of left ventricular remodeling after alcohol septal ablation in hypertrophic obstructive cardiomyopathy
Background - Alcohol septal ablation (ASA) reduces left ventricular outflow tract (LVOT) pressure gradient in patients with hypertrophic obstructive cardiomyopathy (HOCM), which leads to left ventricular remodeling. We sought to describe the early to midterm changes and modulating factors of the remodeling process using cardiac MRI (CMR). Methods and Results - CMR was performed at baseline and 1 and 6 months after ASA in 29 patients with HOCM (age 52±16 years). Contrast-enhanced CMR showed no infarct-related hyperenhancement outside the target septal area. Septal mass decreased from 75±23 g at baseline to 68±22 and 58±19 g (P<0.001) at 1- and 6-month follow-up, respectively. Remote, nonseptal mass decreased from 141±41 to 132±40 and 111±27 g (P<0.001), respectively. Analysis of temporal trends revealed that septal mass reduction was positively associated with contrast-enhanced infarct size and transmural or left-sided septal infarct location at both 1 and 6 months. Remote mass reduction was associated with infarct location at 6 months but not with contrast-enhanced infarct size. By linear regression analysis, percentage remote mass reduction correlated significantly with LVOT gradient reduction at 6-month follow-up (P=0.03). Conclusions - Left ventricular remodeling after ASA occurs early and progresses on midterm follow-up, modulated by CMR infarct size and location. Remote mass reduction is associated with infarct location and correlates with reduction of the LVOT pressure gradient. Thus, myocardial hypertrophy in HOCM is, at least in part, afterload dependent and reversible and is not exclusively caused by the genetic disorder
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